Tuesday, December 8, 2009

182 - Chemical carcinogens - IARC group 1 (selected)



CHEMICAL CARCINOGENPREDOMINANT TUMOR TYPE
AflatoxinsLiver cancer
Benzene Leukemia
CyclophosphamideBladder cancer, Leukemia
Diethyl stilbestrol (DES)Vaginal and clear cell adenocarcinomas
Estrogen replacement
therapy
Endometrial and breast cancers
TamoxifenEndometrial cancer
Tobacco products
(smokeless)
Oral cancer
NickelLung cancer
CadmiumLung cancer
Chromium (VI) compoundsLung cancer
BerylliumLung cancer
Tobacco smokeLung cancer, Oral cancer, Pharyngeal cancer,
Laryngeal cancer, esophageal cancer
(squamous
cell), pancreatic cancer, bladder cancer,
Liver cancer, Renal cell carcinoma, Cervical cancer,
Leukemia
Vinyl chlorideAngiosarcoma of liver, hepatocellular
carcinoma,
brain tumors, lung cancer, malignancies of
lymphatic and hematopoietic system 
ChlorambucilLeukemia
Arsenic Skin cancer
BenzidineBladder cancer
Coal tarSkin cancer and scrotal cancer
Ethylene oxideLeukemia and lymphoma
Chinese style salted fishNasopharyngeal carcinoma
TCDD
(2,3,7,8-tetrachlorodibenzo
-para-dioxin)
Soft tissue sarcoma


*IARC stands for International agency for Research on Cancer.
*Only tumor types for which causal relationships are established are listed here.
*Tamoxifen is shown to prevent contralateral breast cancer.

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