Lynch's syndrome I and II
Associated persons:
Henry T. Lynch
Description:
Lynch syndrome I:
Familial predisposition to colorectal cancer with right-sided predominance. Predominantly early-onset proximal colon carcinomas.
Lynch syndrome II:
Familial predisposition for other primary cancers in addition to the predisposition for colon cancer; site is often female reproductive organs. Predominantly early onset proximal colon carcinoma associated with other extracolonic adenocarcinomas, particularly endometrial carcinoma.
Both disorders are inherited as autosomal dominant traits.
First described 1913 by Alder Scott Warthin, 1867-1931.
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