Monday, December 22, 2008

139 - drugs causing hemolysis in G6PD deficiency


Definite hemolysis

Possible hemolysis

Doubtful hemolysis

Primaquine, dapsone / chlorproguanil

Chloroquine

Quinine

Sulfamethoxazole , dapsone

Sulfasalazine , sulfadimidine

Sulfadiazine , sulfisoxazole

Cotrimoxazole, nitrofurantoin , nalidixic acid , niridazole

Ciprofloxacin, norfloxacin

Chloramphenicol, para amino salicyclic acid

Acetanilide, phenazopyridine

( pyridium )

Aspirin greater than 3 grams per day

Aspirin lesser than 3 grams per day , acetaminophen , phenacetin

Naphthalene, methylene blue

Vitamin C greater than 1 gm, vitamin K analogues, rasburicase

Doxorubicin , probenecid


The drugs in the first row are the anti malarials causing hemolysis in glucose 6 phosphate dehydrogenase ( G6PD ) deficient individuals , the drugs in the second row are the sulfonamides causing hemolysis in glucose 6 phosphate dehydrogenase ( G6PD ) deficient individuals , the drugs in the third row are the antibiotics or antibacterials causing hemolysis in glucose 6 phosphate dehydrogenase ( G6PD ) deficient individuals , the drugs in the fourth row are the analgesics or anti pyretics causing hemolysis in glucose 6 phosphate dehydrogenase ( G6PD ) deficient individuals and the fifth row includes miscellaneous drugs and compounds causing hemolysis in glucose 6 phosphate dehydrogenase ( G6PD ) deficient individuals

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