151 - NIMS MEDICINE february 2009 mcqs

1q: antineutrophilic cytoplasmic ( ANCA ) antibodies are seen in all except ?

a. churg strauss syndrome
b. wegener's granulomatosis
c. microscopic polyangitis
d. polyarteritis nodosa

answer: d . polyarteritis nodosa .

antineutrophilic cytoplasmic antibodies are of two types

1. P - ANCA = perinuclear antineutrophilic cytoplasmic antibodies and

2. C - ANCA = antineutrophilic cytoplasmic antibodies directed against cytoplasmic proteinase-3

the causes of P - ANCA are

a. microscopic polyangitis ( microscopic PAN )
b. churg strauss syndrome
c. cresentric glomerulonephritis
d. good pasture syndrome
e. rarely seen in classic PAN

the causes of C - ANCA are

a. wegener's granulomatosis .

121 - systemic lupus erythematosus mcqs

1q: best screening test for SLE ?

Answer : anti nuclear antibody .

2q: auto antibodies in SLE associated with decreased risk of nephritis and sjogren syndrome ?

Answer : anti Ro and anti La ..

3q: auto antibody correlating with depression or psychosis in SLE ?

Answer : anti ribosomal protein antibody .

4q : auto antibody in SLE associated with subcutaneous and neonatal lupus ?

Answer : anto Ro antibody

5q: auto antibody in SLE correlating with active CNS lupus ?

Answer : anti neuronal antibody .

6q: antibody associated with inflammatory myopathy ?

Answer : anti histidyl t-RNA synthetase antibody .

7q: antibody associated with mixed connective tissue disorder ?

Answer : anto U1 RNP .

8q: antibody associated with sjogren’s syndrome and decreased risk of nephritis ?

Answer : anto Ro and anti La .

9q: anti body associated with diffuse cutaneous scleroderma ?

Answer : anti-topoisomerase 1 antibody, anti RNA polymerase 1,2,3 .

10q: antibody associated with limited cutaneous scleroderma ?

Answer : anti centromere , anti - Th RNP .

11q: most specific autoantibody in SLE ?

Answer : anti double stranded DNA antibody

12q: most frequent autoantibody in drug induced SLE ?

Answer : anti histone antbody .

13q: most specific and sensitive auto antibody in celiac disease ?

Answer : anti endomysial antibody .

14q: anti saccaromyces cervisial antibody is associated with which disease ?

Answer : crohn’s disease ( 60-70 % patients ) and in ulcerative colitis ( 10 -15 % ) .

15q: perinuclear anti neutrophilic cytoplasmic antibody ( p - ANCA ) is associated with which conditions ?

Answer : ulcerative colitis ( 60-70 % ) and in crohn’s disease ( 5 – 10 % ) . other conditions in which p – ANCA are seen are microscopic polyangitis , cresentric glomerulonephritis, churg strauss syndrome, goodpasture syndrome . microscopic polyangitis is another name for microscopic PAN . p – ANCA are rarely present or absent in classic PAN .

16q: c – ANCA antibodies are seen in ?

Answer : cytoplasmic anti neutrophilic antibodies are seen in wegener’s granulomatosis .