1q: best screening test for SLE ?
Answer : anti nuclear antibody .
2q: auto antibodies in SLE associated with decreased risk of nephritis and sjogren syndrome ?
Answer : anti Ro and anti La ..
3q: auto antibody correlating with depression or psychosis in SLE ?
Answer : anti ribosomal protein antibody .
4q : auto antibody in SLE associated with subcutaneous and neonatal lupus ?
Answer : anto Ro antibody
5q: auto antibody in SLE correlating with active CNS lupus ?
Answer : anti neuronal antibody .
6q: antibody associated with inflammatory myopathy ?
Answer : anti histidyl t-RNA synthetase antibody .
7q: antibody associated with mixed connective tissue disorder ?
Answer : anto U1 RNP .
8q: antibody associated with sjogren’s syndrome and decreased risk of nephritis ?
Answer : anto Ro and anti La .
9q: anti body associated with diffuse cutaneous scleroderma ?
Answer : anti-topoisomerase 1 antibody, anti RNA polymerase 1,2,3 .
10q: antibody associated with limited cutaneous scleroderma ?
Answer : anti centromere , anti - Th RNP .
11q: most specific autoantibody in SLE ?
Answer : anti double stranded DNA antibody
12q: most frequent autoantibody in drug induced SLE ?
Answer : anti histone antbody .
13q: most specific and sensitive auto antibody in celiac disease ?
Answer : anti endomysial antibody .
14q: anti saccaromyces cervisial antibody is associated with which disease ?
Answer : crohn’s disease ( 60-70 % patients ) and in ulcerative colitis ( 10 -15 % ) .
15q: perinuclear anti neutrophilic cytoplasmic antibody ( p - ANCA ) is associated with which conditions ?
Answer : ulcerative colitis ( 60-70 % ) and in crohn’s disease ( 5 – 10 % ) . other conditions in which p – ANCA are seen are microscopic polyangitis , cresentric glomerulonephritis, churg strauss syndrome, goodpasture syndrome . microscopic polyangitis is another name for microscopic PAN . p – ANCA are rarely present or absent in classic PAN .
16q: c – ANCA antibodies are seen in ?
Answer : cytoplasmic anti neutrophilic antibodies are seen in wegener’s granulomatosis .
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