121 - systemic lupus erythematosus mcqs

1q: best screening test for SLE ?

Answer : anti nuclear antibody .

2q: auto antibodies in SLE associated with decreased risk of nephritis and sjogren syndrome ?

Answer : anti Ro and anti La ..

3q: auto antibody correlating with depression or psychosis in SLE ?

Answer : anti ribosomal protein antibody .

4q : auto antibody in SLE associated with subcutaneous and neonatal lupus ?

Answer : anto Ro antibody

5q: auto antibody in SLE correlating with active CNS lupus ?

Answer : anti neuronal antibody .

6q: antibody associated with inflammatory myopathy ?

Answer : anti histidyl t-RNA synthetase antibody .

7q: antibody associated with mixed connective tissue disorder ?

Answer : anto U1 RNP .

8q: antibody associated with sjogren’s syndrome and decreased risk of nephritis ?

Answer : anto Ro and anti La .

9q: anti body associated with diffuse cutaneous scleroderma ?

Answer : anti-topoisomerase 1 antibody, anti RNA polymerase 1,2,3 .

10q: antibody associated with limited cutaneous scleroderma ?

Answer : anti centromere , anti - Th RNP .

11q: most specific autoantibody in SLE ?

Answer : anti double stranded DNA antibody

12q: most frequent autoantibody in drug induced SLE ?

Answer : anti histone antbody .

13q: most specific and sensitive auto antibody in celiac disease ?

Answer : anti endomysial antibody .

14q: anti saccaromyces cervisial antibody is associated with which disease ?

Answer : crohn’s disease ( 60-70 % patients ) and in ulcerative colitis ( 10 -15 % ) .

15q: perinuclear anti neutrophilic cytoplasmic antibody ( p - ANCA ) is associated with which conditions ?

Answer : ulcerative colitis ( 60-70 % ) and in crohn’s disease ( 5 – 10 % ) . other conditions in which p – ANCA are seen are microscopic polyangitis , cresentric glomerulonephritis, churg strauss syndrome, goodpasture syndrome . microscopic polyangitis is another name for microscopic PAN . p – ANCA are rarely present or absent in classic PAN .

16q: c – ANCA antibodies are seen in ?

Answer : cytoplasmic anti neutrophilic antibodies are seen in wegener’s granulomatosis .

113 - connective tissue diseases mcqs part 2

1. which of the following antibodies are most specific for SLE ?

a- anti dS-DNA

b- anti SS DNA

c- anti histone

d- anti Ro

answer is a . anti dS-DNA .

2. anti nuclear antibodies are seen in all except ?

a- SLE

b- Systemic sclerosis

c- Morphea

d- Pemphigus vulgaris

Answer is d. pemphigus vulgaris is not characterized by anti-nuclear antibodies .

3. keratoderma blenorrhagica is pathognomonic of ?

a- behcet’s disease

b- reiter’s disease

c- lyme’s disease

d- glucaganoma

answer is b . reiter’s disease .

4. small vessels are involved in ?

a- takayasu arteritis

b- kawasaki’s disease

c- PAN

d- Temporal arteritis

Answer is c . PAN .

5. commonest cardiac lesion in rheumatoid arthritis ?

a- pancarditis

b- pericarditis

c- myocarditis

d- endocarditis

answer is b . pericarditis .

112 - connective tissue disorders mcqs

1. martel’s sign is seen in ?

a- rheumatoid arthritis
b- ankylosing spondylitis
c- gout
d- osteoarthritis

answer is c . martel’s sign is seen in gout .

2. onion skin spleen is seen in ?

a- ITP
b- Thalassemia
c- SLE
d- Scleroderma

Answer is c . SLE .

3. heberden’s nodes are seen in ?

a- rheumatoid arthritis
b- rheumatic arthritis
c- osteoarthritis
d- SLE

Answer is c . osteoarthritis .

4. lupus pernio is ?

a- sarcoidosis
b- skin TB
c- SLE complication
d- DLE and SLE

Answer is a . lupus pernio is sarcoidosis .

5. anti-topoisomerase 1 is a marker of ?

a- systemic sclerosis
b- classic polyarteritis nodosa
c- nephrotic syndrome
d- rheumatoid arthritis

answer is a. systemic sclerosis .