17 - pulmonary arterial hypertension mcqs

Question 1
Pulmonary arterial hypertension is defined by a mean pulmonary arterial pressure:
20mm Hg at rest or >25mm Hg with exercise.
25mm Hg at rest or >30mm Hg with exercise.------------
30mm Hg at rest or >35mm Hg with exercise.
35mm Hg at rest or >40mm Hg with exercise.

Question 2
Normal mean pulmonary artery pressure remains:
1/6th of mean systolic arterial pressure-------------
1/5th of mean systolic arterial pressure
1/4th of mean systolic arterial pressure
1/3rd of mean systolic arterial pressure

Question 3
Currently accepted classification of pulmonary arterial hypertension does not include which of the following?
Primary pulmonary arterial hypertension------------
Idiopathic pulmonary arterial hypertension
Familial pulmonary arterial hypertension
Associated with pulmonary arterial hypertension

Question 4
Which of the following is known to be associated with an increased risk of pulmonary arterial hypertension?
Cocaine-----------
Marijuana
Both of the above
None of the above

Question 5
Which of the following is a secondary cause of pulmonary arterial hypertension?
Collagen vascular diseases
Human immunodeficiency virus (HIV)
Chronic obstructive pulmonary disease
All the above-----------------

Question 6
Which of the following statements regarding the symptoms of pulmonary arterial hypertension (PAH) is true?
The early and most common symptom of PAH are dyspnea and fatigue
Many signs of PAH are consistent with heart failure
Rare symptoms associated with PAH include ascites and pedal edema
All of the above----------------

Question 7
Which of the following is not a diagnostic sign of pulmonary arterial hypertension?
Distended jugular vein
Pansystoloic murmur
Accentuated pulmonary component of S 2
Abnormal lung sounds---------------

Question 8
In patients with pulmonary arterial hypertension, oxygen saturation should be maintained at greater than:
80% at all times
85% at all times
90% at all times------------
95% at all times
Question 9
Which of these may be used for management of pulmonary arterial hypertension?
Calcium channel blockers
Prostacyclins
Bosentan
All of the above---------------

Question 10
Phosphodiesterase isoenzyme-type 5 (PDE-5) are present in:
Corpus cavernosum
Vascular smooth muscle
Platelets
All the above---------------

Question 11
Which of these PDE- 5 inhibitor is approved by US FDA for managing pulmonary arterial hypertension?
Tadafil
Sildenafil-------------
Vardenafil
All of the above

Question 12
Use of sildenafil is contraindicated with:
Amyl nitrate
Isosorbide dinitrate
Nitroglycerine
All of the above------------

Question 13
Which of these is an appropriate starting dosage regimen for sildenafil in pulmonary arterial hypertension?
20mg Two times daily
20mg Three times daily--------------
30mg Two times daily
30mg Three times daily

Question 14
Of the following, which is a synthetic prostacyclin?
Iloprost
Epoprostenol-----------
Sodium Beraprost
None of the above

Question 15
Which of these prostacyclin is active when administered orally?
Iloprost--------------
Epoprostenol
Sodium Beraprost
Treprostinil