5 - epilepsy mcqs

Question 1
According to recent data the two general categories of epilepsy are ?
Petitmal and grandmal
Localization-related and generalized------------------
Partial and complete
Simple motor and psychomotor

Question 2
The highest incidence of epilepsy is in ?
Children---------------------
Adolescents
Young to middle-aged adults
The elderly

Question 3
In the majority of patients who have had a single seizure, the evaluation shows ?
A history of seizures in a sibling
A history of CNS damage (e.g. head injury or stroke)
Abnormality on the EEG
No abnormality on the history, EEG, or MRI-------------------

Question 4
Which of the following statements about juvenile myoclonic epilepsy is false ?
It has a genetic basis, possibly with a gene locus on chromosome 6
Presence of a specific pattern on EEG makes the diagnosis almost certain---------------
MRI is of little value in the diagnosis
Sodium channel anticonvulsants (e.g. phenytoin and carbamazepine) are the drugs of choice for treatment

Question 5
Characteristic features of temporal lobe epilepsy include ?
Complex partial seizure with loss of awareness
Hallucinations of smell, taste, learning or vision
Deja vu phenomenon associated with intense emotion
All of the above--------------

Question 6
Conventional antiepileptic drugs are ineffective in ?
2% of patients
25-30% of patients------------
40% of patients
60% of patients

Question 7
Absence seizures are aggravated due to ?
Phenytoin
Sodium valproate
Clobazam
Carbamazepine----------------

Question 8
Rational polytherapy is defined as ?
Combining drugs belonging to same class
Combining drugs with pharmacodynamic interactions
Combining drugs with different mechanisms of action and belonging to different classes-------------
Combining drugs with diverse pharmacokinetic profile

Question 9
A non dose-related side effect of valproic acid more commonly seen in women is ?
Weight gain------------
Skin rash
Hepatotoxicity
Gingival hypertrophy

Question 10
Catamenial epilepsy appears to be related to a relative lack of ___________ during the luteal phase of the cycle.
Progesterone-------------
Oestrogen
Progesterone and oestrogen
Serotonin

Question 11
Amongst the new antiepileptic drugs ___________________________ is approved as monotherapy in adults.
Vigabatrin
Gabapentin
Lamotrigine--------------
Felbamate

Question 12
Lamotrigine is effective in:
Partial seizures
Generalized seizures
Absence seizures
All types of seizures-----------

Question 13
Lamotrigine is the drug of choice in:
West Syndrome
Juvenile myoclonic epilepsy
Typical Absence Epilepsy
Lennox Gastaut Syndrome--------------

Question 14
10. Sodium valproate displays synergism with:
Lamotrigine
Carbamazepine---------------
Clobazam
Gabapentin

Question 15
Positive effects on cognition are displayed with ?
Carbamazepine
Benzodiazepine
Lamotrigine--------------
Phenobarbitone

Question 16
Positive psychotropic effects occur with antiepileptic drugs having ?
Glutamatergic mechanisms of action-------------
GABAergic activity
Serotonergic action
Calcium blocking action

Question 17
Lamotrigine is a favorable choice for elderly patients with epilepsy due to:
Low frequency of interactions with non-AEDs
Novel mechanism of action
Wide spectrum of action
All of the above-------------

Question 18
Lamotrigine has shown promise in non-epileptic condition such as ?
Bipolar Disorder-------------
Schizophrenia
Cerebral Palsy
Anxiety

Question 19
Lamotrigine has been used in ____________________ patients world-wide
500 patients
10,000 patients
1 lakh patients
1.386 million patients---------------

Question 20
Lamotrigine has shown efficacy ?
Comparable to phenytoin and carbamazepine------------
Greater than phenytoin and carbamazepine
Less than phenytoin and carbamazepine
Comparable to phenobarbitone