9 - rheumatoid arthritis

Question 1
Typical rheumatoid arthritis is characterized by
Symmetric inflammatory polyarthritis
Sparing of axial skeleton except cervical spine
Sparing of distal interphalangeal joints
All of the above--------------

Question 2
Which of these is not a feature of rheumatoid arthritis?
Swollen joints
Painful joints
Morning stiffness
Headache---------------

Question 3
The exact etiology of rheumatoid arthritis is not known but all the following have been implicated as having a role in its causation ,except
Genetic factors
Autoimmunity
Microbial infection
Low calcium levels in the body-----------

Question 4
Rheumatoid arthritis is a mutisystem disorder. It can involve any of the following, except
Eyes
Lungs
Heart
Ear---------------

Question 5
What is true regarding the prevalence of rheumatoid arthritis?
More common in females but difference reduces in older age group-------------
More common in females but difference is less in younger age group
More common in males but difference reduces in older age group
More common in males but difference is less in younger age group

Question 6
Rheumatoid factors are autoantibodies found in many individuals. Their importance in rheumatoid arthritis is as a
Prognostic factor---------------
Screening factor
Diagnostic factor
None of the above

Question 7
Features that signify a bad prognosis in rheumatoid arthritis are
High titer of rheumatoid factor
Presence of subcutaneous nodules
Radiographic evidence of erosion at the time of initial evaluation
All of the above----------------

Question 8
The goals of therapy of rheumatoid arthritis are
Reduction of pain and inflammation
Maintenance of function and movement
Control of systemic involvement
All of the above-------------

Question 9
NSAID are used as the first line of treatment for rheumatoid arthritis because of their
Anti-inflammatory properties----------
Immunosuppresive properties
Cytotoxic properties
Tumor necrosis factor inhibitor properties

Question 10
The newly discovered COX-2 inhibitors are considered superior to standard NSAID because they have
Less gastro-intestinal side effects------------
Minimal renal toxicity
Slow the progress of the disease
None of the above

Question 11
Corticosteroids used for management of rheumatoid arthritis have all these properties, except
Reduce inflammation and swelling
Beneficial for systemic involvement in rheumatoid arthritis
Can be taken orally or as an injection
Delayed onset of action----------------

Question 12
DMARDs are a group of diverse agents that slow down the progress of rheumatoid arthritis. All is true with regard to DMARDs, except
Benefit is noticed after 2-6 months
These are generally prescribed along with NSAID or steroids
Work by slowing the immune system from attacking the joint
None of these are used for treating disorders other than rheumatoid arthritis----------------

Question 13
Leflunomide is a newly approved DMARD. It should not be prescribed to
Elderly men
Children
Pregnant women-----------
Elderly women

Question 14
Biologic response modifiers are drugs that target the immune factors, particularly Tumor Necrosis Factor (TNF) which play a major role in the destructive process. Which of these drugs belong to this class of drugs?
Etanercept------------
Celecoxib
Rofecoxib
Penicillamine

Question 15
Agents that are being studied for benefits in rheumatoid arthritis are
Soluble collagen
Thalidomide
Protease inhibitors
All the above-----------------