20 - inhaled corticosteroids mcqs

Question 1
Ideal inhaled corticosteroid should have:
High pulmonary residence time
High protein binding after leaving the lungs
High systemic clearance
All the above---------------

Question 2
Which statement is not true with regard to corticosteroid receptors?
They are intracellular
Same receptor mediates both beneficial and adverse effects of coticosteroid
There are no coticosteroid receptors in the eye lens
None of the above-----------------

Question 3
The latest addition to the list of inhaled corticosteroid is:
Ciclesonide-------------
Budesonide
Beclomethasone dipropionate
Fluticasone propionate

Question 4
Which of the following formulations gives the highest drug deposition in the lungs?
Powder
Suspension
Solution----------
Is equal with all of the above

Question 5
Of the following, which drug has highest receptor affinity?
Fluticasone propionate--------------
Dexamethasone
Beclomethasone dipropionate
Desisobutyryl – ciclesonide

Question 6
Which of the following corticosteroids is inhaled in pharmacologically inactive form?
Beclomethasone dipropionate------------
Fluticasone propionate
Dexamethasone
None of the above

Question 7
Which of these statements is false? In approved dosages inhaled corticosteroids:
Inhibit proliferation of inflammatory cells
Do not suppress endogenous cortisol release
Do not cause osteoporosis
None of the above-------------

Question 8
Which of these statements is true? In approved dosages inhaled corticosteroids cause:
Weight gain
Glaucoma
Cataract
None of the above------------

Question 9
Which of these is a side effect of oral but not of inhaled corticosteroids when given in recommended dosage?
Moon face
Increased risk of fracture
Disturbed carbohydrate metabolism
All of the above-------------

Question 10
Which of the following statements is not true with regard to use of inhaled corticosteroid ?
It should be used as first line therapy in asthma
It should be used as first line therapy in chronic obstructive pulmonary disease-------------
It should not be used in children
None of the above

Question 11
Inhaled corticosteroids are used as first line therapy in:
Mild persistent asthma
Moderate persistent asthma
Severe persistent asthma
All the above--------------

Question 12
Which of these statements is true with regard to growth in children with asthma?
Uncontrolled asthma can affect growth
Inhaled corticosteroid with low oral bioavailibility should be used
Inhaled corticosteroid in recommended dosage do not prevent children from reaching adult height
All the above------------

Question 13
What percentage of ciclesonide is deposited in the lung when delivered via the inhaled route?
10% - 20%
21% - 30%
31% - 40%
>50%-----------------

Question 14
Ciclesonide is the safest inhaled corticosteroid because:
Of low oro-pharyngeal deposition
It has high plasma protein binding
Of rapid clearance
All the above statements are true--------------

Question 15
Recommended dosage of ciclesonide in asthma is:
80 – 640 mcg once daily--------------
640 -800 mcg once daily
800 – 1000 mcg once daily
1000 – 1640 mcg once daily