40 - clotting factors 13 list

Primary Factors

Factor	Trivial Name(s)	Pathway	Characteristic
Prekallikrein (PK)	Fletcher factor	Intrinsic	Functions with HMWK and factor XII
High molecular weight kininogen (HMWK)	contact activation cofactor; Fitzgerald, Flaujeac Williams factor	Intrinsic	Co-factor in kallikrein and factor XII activation, necessary in factor XIIa activation of XI, precursor for bradykinin (a potent vasodilator and inducer of smooth muscle contraction
I	Fibrinogen	Both	-
II	Prothrombin	Both	Contains N-term. gla segment
III	Tissue Factor	Extrinsic	-
IV	Calcium	Both	-
V	Proaccelerin, labile factor, accelerator (Ac-) globulin	Both	Protein cofactor
VI (same as Va)	Accelerin	Both	This is Va, redundant to Factor V
VII	Proconvertin, serum prothrombin conversion accelerator (SPCA), cothromboplastin	Extrinsic	Endopeptidase with gla residues
VIII	Antihemophiliac factor A, antihemophilic globulin (AHG)	Intrinsic	Protein cofactor
IX	Christmas Factor, antihemophilic factor B,plasma thromboplastin component (PTC)	Intrinsic	Endopeptidase with gla residues
X	Stuart-Prower Factor	Both	Endopeptidase with gla residues
XI	Plasma thromboplastin antecedent (PTA)	Intrinsic	Endopeptidase
XII	Hageman Factor	Intrinsic	Endopeptidase
XIII	Protransglutaminase, fibrin stabilizing factor (FSF), fibrinoligase	Both	Transpeptidase